Radioisotopic evaluation of bone quality (with the own method and program) as a complementary investigation of bone metabolism in the healthy controls and in the diagnostics of osteopenia and osteoporosis

Introduction: The current definition of osteoporosis puts a greater emphasis on the risk of break age, changes the diagnostic and therapeutic qualifications from the densitometric parameters to the other factors increasing the risk of break age and the evaluation of the bone quality and metabolism, which is measurable by isotopic methods. Material and methods: In the study the bone metabolism rate (WMK) in healthy controls and patients with osteopenia and osteoporosis. The correlation of WMK results and densitometric examinations was defined and their clinical use fulness in the diagnostics and treatment of osteoporosis was evaluated. BMD and WMK underwent statistic analysis. With the 95% confidence interval the correlation and relevance force were calculated. Results: The decreasing of WMK was observed together with the lowering of BMD. WMK showed an important difference in the healthy women and women with osteopenia and osteoporosis, which confirms its diagnostic usefulness. The values of WMK and BMD show a strong plus correlation and are representative for the examined groups of women. The fact that these methods are complementary brings more clinically important information concerning the advancement of osteoporosis. Conclusions: The statement of abnormal BMD and WMK values allows for evaluation of the size of these disturbances and gives a widening of clinically important information in the diagnostics and treatment of bone system. (Clin. Exp. Med. Lett. 2006; 47(4):235-240)

Keywords: bones, Metabolism, Osteoporosis, scintigraphy