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The application of graphical diagnostics for the assessment of the influence of diabetes 2 and hyperthyroidism and hypothyroidism on the lower limbs perfusion and mineral density and metabolism of bones

Wiesław Tryniszewski, Mariusz Gadzicki, Zbigniew Maziarz

Med Sci Tech 2008; 49(3): RA137-144

ID: 881619

Available online:

Published: 2008-03-21


Introduction: The assessment of bone mineralization, metabolism and muscle perfusion disturbances in diabetes and thyroid diseases is clinically important. The assessment of diagnostic usefulness of bone metabolism index (WMK) and muscle perfusion (WP) in diabetes and those diseases is also crucial together with the co-relation between BMD and WMK. Material and methods:The patients with hyper- and hypothyroidism and diabetes 2. The definition of vascular indexes with Doppler method, inclusive for the groups. Densitometric examinations BMD, T-score, Z-score of femoral bone neck. Bone and muscle scintigraphy with the use of own programs for WMK and WP determination. Results: Diabetes – perfusion impairment at rest, perfusion impairment at rest, improving or becoming normal after exercise in 30%. Normal WMK and BMD in 90%. Hyperthyroidism- normal or increased perfusion undergoes the increase after exercise. In 68% osteopeny and in 21% of the patients, osteoporosis were observed. WMK in 90% was within normal values. Hypothyroidism – in 60% a slight perfusion impairment changed insignificantly after exercise. 90% - normal mineral density. 65%, normal and 35%, lowered WMK. No important dependency between WP and WMK was stated. Conclusions: In diabetes 2 the lower limbs muscle perfusion impairment at rest improves or becomes normal after exercise. In hyperthyroidism a lower BMD was observed with the normal WMK. Perfusion increased after exercise. Hypothyroidism doesn’t significantly influence the bone mineral density and metabolism. Bone metabolism index reflects the speed of metabolic processes, showing the plus co-relation wit densitometric examinations, however it doesn’t always show the same change direction. (Clin Exp Med Lett 2008; 49(3): 137-144)

Keywords: scintigraphy, Densitometry, thyroid, diabetes, Metabolism



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