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Influence of laparoscopic adjustable gastric banding on concentration of ghrelin and leptin

Tomasz Szewczyk, Przemysław Janczak, Krystyna Wyka, Olga Wegner, Bogdan Modzelewski

Med Sci Tech 2009; 50(3): RP187-191

ID: 881689

Available online:

Published: 2009-03-22


Introduction: Ghrelin and leptin are hormones affecting the fat and carbohydrate metabolisms of the body related to food intake. Concentration fluctuations depending on a kind and volume of sustenance have an effect on body mass. Concentrations of the hormones reach their peak values in patients suffering from pathological obesity. Changes in the concentrations of ghrelin and leptin can be effected by administering pharmacological remedies or through a surgical limitation of the possibility of food intake. Laparoscopic adjustable gastric banding is one of the restrictive methods for surgical treatment for obesity. Aim of the study: The aim of the study was an evaluation of behavior of the concentrations of ghrelin and leptin in pathologically obese persons and an effect of overweight reduction thereon. Material and methods: The examination comprised 50 patients subjected to the laparoscopic adjustable gastric banding procedure in the Clinic in 2007. The therapeutic indication for the surgery was pathological obesity. The concentrations of ghrelin and leptin in the patients' blood were determined before eating prior to the procedure and after 3 and 6 months. Results: The average BMI amounted to 45.77 kg/m2 before the surgery, 39.95 kg/m2 three months after the operation and 34.95 kg/m2 six months thereafter. The percentage excess weight loss was 29.41% three months after the procedure and 54.35% six months thereafter. The initial concentration of leptin came to an average of 93.84 ng/ml, decreasing up to 61.22 ng/ml three months after the surgery and 42.01 ng/ml six months thereafter. The average concentration of ghrelin a day before the operation was 45.7 pg/ml, amounting to 53.7 pg/ml three months later and 61.47 pg/ml six months thereafter. The concentration of leptin prior to the surgery correlated with the patients’ initial body mass (r=0.53), excess weight (r=0.71) and BMI (r=0.72). It dropped significantly after three and six months thereafter, still showing statistically characteristic correlations with the foregoing parameters. No statistically significant correlation between the concentration of ghrelin prior to the surgery and excess weight and body mass expressed as BMI was found. Three months after the surgery the ghrelin concentration increased insignificantly, showing no correlation with the BMI and percentage excess weight loss. Six months after the procedure the statistical correlations were similar. Conclusions: Laparoscopic adjustable gastric banding is an effective method for obesity treatment. Concentrations of leptin and ghrelin measured before the surgery have no prognostic value with reference to a reduction in body mass in patients after the operation. (Clin Exp Med Lett 2009; 50(3):187-191)

Keywords: Leptin, laparoscopic adjustable gastric banding



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