Clinical Observation of Effect of Diosmin Combined with Jinshuibao Capsule Treatment on Improvement of Semen Quality in Patients with Varicocele

BACKGROUND: Diosmin is widely used in clinical practice. Jinshuibao capsules are made from fermented Cordyceps sinensis bacteria powder, which is similar to Cordyceps sinensis. We aimed to observe the effect of Diosmin combined with Jinshuibao capsule treatment on improvement of semen quality in patients with varicocele (VC).
MATERIAL AND METHODS: We randomly divided 147 male infertility patients with VC into 3 groups. The Treatment Group consisted of 49 patients orally administered Diosmin (2 tablets twice a day), Jinshuibao capsule (3 tablets twice a day), and zinc selenium (2 pills twice a day). Control Group 1 consisted of 48 patients orally administered zinc selenium (2 pills twice a day). Control Group 2 consisted of 50 patients orally administered Jinshuibao (3 tablets twice a day and zinc selenium (2 pills twice a day). Each group received a 3-month course of treatment.
RESULTS: The survival rate of sperm and percentage of grade I sperm were obviously increased in the treatment group compared to the control groups after 3-month treatment (P<0.01). The fragmentation index of sperm DNA and rate of abnormal sperm nucleoprotein were significantly reduced in the treatment group.
CONCLUSIONS: Diosmin combined with Jinshuibao capsule therapy improves semen quality in patients with VC and curative effect is superior to that of zinc selenium alone or combined with Jinshuibao.

Keywords: Diosmin, semen analysis, Varicocele