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Gastric mucins are acid source

Wojciech Janusz Baranowski

Med Sci Tech 2007; 48(1): CR61-63

ID: 881531


Introduction: Spectrophotometric study showed that gastric mucus mucins were able to release H+ ions in hydrolytic processes in absence of parietal cells. Objective: ThestudyoftheinfluenceofNaCl,NaHCO3 and Na2CO3 on the pH value of gastric mucus mucins solutions. Material and Methods: The mucins (0;50;400;1300;2000 mg) were dissolvedin 100 ml aqueous solutions containing: 1) 0.02% Na2CO3; 2) 0.9% NaCl and 0.05% Na2CO3; 3) 0.9% NaCl and 0.08% Na2CO3; 4) 0.9% NaCl, 0.05% Na2CO3 and 0.01% NaHCO3. Results: The pH value was decreasing in all solutions with increasing the mucins concentration not less than to the value around 4. The greatest pH decrease (9.42 → 4.40) was observed in the solution 3. The lowest pH value by contrast(6.09 → 3.50) was reached in the solution 1. In the solutions 2 pH values decreased 6.47 → 3.87 and 6.63 → 4.03 in the solution 4. Conclusions: In NaCl, Na2CO3 and NaHCO3 presence (solutions 1, 2 and 4) fair quantities of H+ ions are releasing from the mucins of the gastric mucus. The process creates acidity that is typical for the digestion. The new theory of the gastric acidformation was proposed on this basis - H+ ions are being assigned in the tied form, as mucins of gastric mucus. The adjustment of the acidity of gastric juice consists in the change of the quantity and the composition permeat of blood, that getting through from the lumen of blood vessels to the lumen of the stomach and diluting mucus and makes releasing H+ ions in the consequence of its hydrolysis.(Clin Exp Med Lett 2007; 48(1):61-63)

Keywords: Mucus, Mucins, HCI, secretion, proton

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