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Environmental factors and the risk of colorectal adenomas and cancer

Marta Słomka, Aleksandra Kaczka, Ewa Małecka-Panas

Med Sci Tech 2008; 49(2): RP77-81

ID: 881602

Colon carcinogenesis is a multi-step process and the sequence of changes: normal mucosa – colon adenoma – carcinoma is well documented. Although genetic alterations are essential for the process, environmental factors such as macro – and micronutrients, tobacco, alcohol and physical activity and their potential influence on colorectal cancer development are widely discussed. However the underlying mechanisms are not always clear, the results of the epidemiological and casecontrol studies indicate definitely that the change of lifestyle, avoiding obesity, increased physical activity, change of eating habits in favour of vegetables and fruits, decreased consumption of red meat in favour of multiunsaturated fatty acids may significantly influence the reduction of the risk of colorectal cancer. (Clin Exp Med Lett 2008; 49(2): 77-81)

Keywords: colorectal tumors, Risk Factors

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