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Helicobacter pylori – associated gastritis in different forms of functional dyspepsia The infection of Helicobacter pylori in functional dyspepsia

Kamila Olszowiec, Grażyna Kulig, Grażyna Klupińska, Ewa Walecka-Kapica, Krystyna Stec-Michalska, Cezary Chojnacki

Med Sci Tech 2009; 50(3): RA131-135

ID: 881685


Introduction: “Functional dyspepsia” defines gastroduodenal symptoms not explained by any organic disease. Moreover, two clinical forms of this disease have been distinguished: postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). The role of H. pylori infection still remains under debate. The aim of the study was to determine whether the density of H. pylori colonization and the immune response to the infection are similar in different forms of functional dyspepsia. Material and methods: the study involved 30 subjects without dyspeptic ailments (K), 30 with PDS and 30 with EPS. The diagnosis was based on Rome Criteria III. The subjects were selected randomly after earlier detection of anti- H. pylori antibodies in serum with serological method. H. pylori infection was confirmed with urea breath test. Results: mean serum concentration of anti- H. pylori antibodies in subjects with asymptomatic infection was 89.90 ± 48.16 U/L. These values were similar in PDS group and they were: 71.53 ± 36.13 U/L (p>0.05). Statistically significantly higher values of this concentration were found in EPS group and they were: 264.55 ± 98.20 (p<0.01). Similar differences were observed in the values of urea breath test. In the groups of patients with asymptomatic infection and dyspepsia in the form of PDS the results were similar: 14.77 ± 5.13‰ and 15.10 ± 5.75 ‰, respectively (p>0.05). In patients with EPS the values of breath test were significantly higher - 26.44 ± 14.01‰ (p<0.001). Conclusions: 1. The results of urea test and the serum concentration of anti- H. pylori antibodies are different in different forms of functional dyspepsia. 2. Density of H. pylori colonization and immune response to the infection affect the clinical picture of functional dyspepsia. (Clin Exp Med Lett 2009; 50(3):131-135)

Keywords: Helicobacter pylori, density of colonization, functional dyspepsia

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