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AmJCaseRep

Study of heart rate autonomic modulation in patients with asthma disease

Victor Francisco Souza, Ivan Peres Costa, Audrey Borghi Silva, Diego Holanda Lacerda, Dirceu Costa, Claudia Santos Oliveira, Vera Lucia Santos Alves, Roberto Stirbulov, Luis Vicente Franco de Oliveira, Luciana Maria Malosa Sampaio

Med Sci Tech 2010; 51(2): 113-116

ID: 881264

Available online:

Published: 2010-11-15


Background:    Evaluate the autonomic activity of patients with asthma in moderate supine and sitting positions.
    Material/Methods:    Twenty individuals with asthma and 10 healthy individuals were studied. Heart rate and electrocardiographic R-R intervals (iR-R) were recorded for 360 seconds in the supine and seated positions. Heart rate variability was analyzed in the time domain (TD) (RMSSD index, ie, the root mean square of the squares of the differences between successive iR-R records; and the SDNN index, ie, the mean standard deviation of normal iR-R in ms) and in the frequency domain (FD), from the low-frequency (LF) and high-frequency (HF) bands in absolute units (au) and normalized units (nu), and the LF/HF ratio.
    Results:    In TD, the asthma group (AG) presented significantly higher values for the RMSSD and the SDNN in the seated position, compared with the control group (CG). In FD, the AG presented significantly higher values for HF components, in the supine position, and for LF components, and HF in the seated position.
    Conclusions:    Patients with asthma present reduced HRV when compared with healthy sex- and age-matched controls, with the reduction in sympathetic and vagal activity. Furthermore, both patients and healthy individuals with asthma do not present autonomic adjustments with front postural change. Future studies should examine the HRV as a useful tool to obtain parameters for the stratification of cardiovascular risk in this population, and in the evaluation of different physical therapy interventions designed to treat these patients.

Keywords: : heart rate variability, asthma, autonomic nervous system, resting condition, : heart rate variability, asthma, autonomic nervous system, resting condition, heart rate variability, asthma



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