e-ISSN 2329-0072




The effect of magnetotherapy and magnetostimulation on cytokine release by human peripheral blood lymphocytes in vitro

Adam Miecznik, Ewa Fornalczyk-Wachowska, Krzysztof Zeman, Jan Czernicki

Med Sci Tech 2007; 48(2): RA111-115

ID: 881553

Available online:

Published: 2007-03-18

Introduction:.Owing to its anti-inflammatory, anti-oedematous, anaelgesic, and angiogenetic properties, the electromagnetic field (EMF) has multiple medical applications, mainly in the physiotherapy of various conditions. In many cases, physiotherapy with EMF can exert a direct or indirect effect on the immune system. The aim of the project was to assess the impact that magnetotherapy and magnetostimulation may have on the activity of peripheral blood lymphocytes from healthy individuals. Material and Methods: Human peripheral blood lymphocytes obtained from 28 healthy male subjects were exposed to EMF via magnetostimulation (2 programmes, Viofor JPS device) or magnetotherapy (2 programmes, Magnetronik MF-10). Cytokine release (TNF-α, IL-10, IL-1β, IL-12, IL-8) by resting and phytohemagglutinin-activated lymphocytes was determined. Results: Magnetostimulation programme M2P3 was found to induce increased TNF-α and IL-8 levels. Mitogen stimulation had no effect on the secretory activity of peripheral blood lymphocytes. Magnetotherapy contributed to increased concentration of IL-10 released by resting and PHA-activated peripheral blood lymphocytes in both the programmes under study. Conclusions: Cytokine release by peripheral blood lymphocytes exposed in vitro to EMF depends on the physical parameters of the EMF applied. When appropriate therapeutic programmes are used, both magnetotherapy and magnetostimulation have influence on the activity of pro- or anti-inflammatory cytokines. (Clin Exp Med Lett 2007; 48(2): 111-115)

Keywords: Electromagnetic Fields, magnetostimulation, magnetotherapy, Immunity, Lymphocytes, Cytokines