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AmJCaseRep

The frequency of appearance of the ID ACE genetic polymorphism in patients with previous myocardial infarction in Polish population

Krzysztof Chiżyński, Elżbieta Cieplucha

Med Sci Tech 2007; 48(3): RA173-179

ID: 881562

Available online:

Published: 2007-03-20


Introduction: Inconsistent results have been reported regarding the association of ACE polymorphism with coronary artery disease. Several studies showed a positive association between the ACE D/D genotype and an increased risk of myocardial infarction. In the present study, an attempt has been made to identify whether I/D ACE polymorphism has positive association with previous MI in Polish population. Material and methods: 175 patients with previous MI were enrolled to the study group. The control group contained 95 patients without CAD (with angiographically normal coronary arteries). To determine the ACE genotype, genomic DNA was amplified by PCR initially using a flanking primer pair, and subsequently, when necessary, with a primer pair that recognizes the I-specific sequences for confirmation of the specificity of the amplification reactions. Results: Among 175 subjects with previous MI enrolled in the study, 65 (37.2%) had a DD genotype, 55 (31.4%) had ID and 55 (31.4%) had II genotype. In the control group there was less patients with DD genotype [23 pts (24.2%); p<0.05] and more patients with II genotype [42 (44.2); p<0.05] comparing to the study group. The DD ACE genotype was related to the previous MI (p<0.05). Odds ratio for MI in subjects with DD ACE genotype was 1.85 (1.07-3.21) (p<0.05). The genotype with D allele (DD and ID genotypes) was related to the previous MI. (p<0.05). Odds ratio for MI in subjects with D allele (DD and ID ACE genotypes) was 1.73 (1.03-2.89) (p<0.05). The D allele frequency was 52.9% in the study group and 40% in the control group (p<0,005). The I allele frequency was 52.9% and 60% respectively (p<0.005). Odds ratio for MI in subjects with D allele was 1.68 (1.18-2.40) (p<0.005). Conclusions: On the basis of our data, ACE DD genotype or genotype with D allele seems to be a potent MI risk factor in Polish population. (Clin Exp Med Lett 2007; 48(3):173-176)

Keywords: MI, Risk Factors, I/D ACE polymorphism



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