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AmJCaseRep

Postoperative inflammatory reaction in patients after open vs. laparoscopic gall bladder surgery

Piotr Jurałowicz, Paweł Czekalski, Adam Janiak, Bogdan Modzelewski, Janusz Wasiak

Med Sci Tech 2009; 50(3): RA183-186

ID: 881681

Available online:

Published: 2009-03-22


Introduction: Laparoscopic gall bladder surgery has proven over the years to have many advantages, one of which may be the lesser extent of surgical trauma to the patient as compared to the open method. Aim of study: To determine the extent of surgical trauma by means of perioperative inflammatory reaction assessment after laparoscopic and open cholecystectomy. Material and methods: Study was conducted on 40 patients operated on because of symptomatic gall bladder stones, 20 of whom underwent laparoscopy, and 20 – open surgery. In all patients, serum levels of C-reactive protein, IL-6, hydrogen peroxide, lipid peroxidation products (conjugated dienes, malonyl dialdehyde, Schiff’s bases), and white blood cell count were measured before and on the 1st, 3rd, and 7th day after surgery. Results: Laparoscopic surgery caused a slight, insignificant rise in serum CRP level. After open procedure, high levels of CRP persisted throughout subsequent measurement time points, significantly higher as compared to laparoscopy. Statistics showed higher values of IL-6 in laparoscopy group on 1st and 3rd day after surgery. Moreover, our study revealed, that pro- and anti-oxidativem balance remained stable after both types of treatment, making anti-oxidative response slightly more pronounced after open surgery. Conclusions: Open cholecystectomy causes a stronger perioperative systemic inflammatory response than laparoscopy. (Clin Exp Med Lett 2009; 50(3):183-186)

Keywords: inflammatory reaction, Cholecystectomy



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