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Multiple cancers syndrome: Case report of synchronous appearance of four types of malignant cancer

Michalina Olejniczak, Dorota Snopkowska-Wiaderna, Leszek Kutwin, Krzysztof W. Zieliński

Med Sci Tech 2011; 52(1-2): CR83-86

ID: 882083

Available online:

Published: 2011-10-28

Background:    Malignant synchronous tumors (2 or more simultaneously diagnosed cancers in 1 person) constitute 1% of all oncological cases. In this group the most common are multifocal proliferations in the same system or organ. Multifocal proliferations in more than 2 places or organs are very rare and there are few reports of these in the literature.
    Case Report:    The paper presents the case of four histologically different primary cancers. Sites of these tumors were the gallbladder (adenosquamous carcinoma), the hepar (neuroendocrine carcinoma) and right kidney (the focus of renal cell carcinoma and chromophobe cell carcinoma). The histological nature of these tumors was confirmed immunohistochemically.
    Conclusions:    Although in recent years there has been an increase in cases with 2 or more different primary cancers, still, most of them concern metasynchronous tumors. Therefore, simultaneous detection of different primary tumors is based upon actual cases or case histories. In the presented case is noteworthy both for the occurrence of synchronous tumors and their unusual composition and histological types. In the differential diagnosis, von Hippel-Lindau, Brit-Hogg-Dube and Lynch II syndromes should be especially considered.

Keywords: quadruple synchronous cancer, gallblader adenosquamous carcinoma, neuroendocrine liver carcinoma, clear cell renal carcinoma, Chromophobe renal cell carcinoma