e-ISSN 2329-0072




Primary hyperparathyroidism clinically presenting as multifocal giant cell tumor – a case report

Magdalena Górska-Chrząstek, Lech Pomorski, Mariusz Gadzicki, Jacek Makarewicz, Wiesław Tryniszewski, Iwona Raciborska, Zbigniew Maziarz

Med Sci Tech 2012; 53(3): CR129-135

ID: 883612

Available online:

Published: 2012-12-03


Background:    Primary hyperparathyroidism is one of the most common endocrinopathies and affects 0.1–0.3% of the population. Giant cell tumor, which occurs in 4–8% of primary bone tumor cases, is characterized by a variety of clinical behaviors and radiological images. In the course of those 2 diseases, radiological and histopathological images of the bone lesions can by very similar.
    Case Report:    We describe the natural history, clinical presentations, and the diagnostic process of multifocal lesions in bones, histopathologically recognized as the foci of giant cell tumor, which finally turned out to be the foci of bone destruction (brown tumors) in the course of primary hyperthyroidism caused by adenoma.
    Conclusions:    In the course of bone lesions, a designation of basic parameters of calcium – phosphor balance is crucial for the detection of hypercalcemia. Designation of PTH level allows for the differentiation between these disease entities.

Keywords: primary hyperparathyroidism, brown tumors, Giant cell tumor