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Serum adiponectin, leptin and soluble leptin receptor concentrations after acute coronary syndrome in males, attendants of early cardiac rehabilitation

Barbara Kopff, Katarzyna Szmigielska, Michał Chwałkiewicz, Anna Jegier

Med Sci Tech 2010; 51(2): 5-9

ID: 881253


Background:    Adiponectin, leptin, and soluble leptin receptor (sObR) have important effect on atherosclerosis and its complications – coronary artery disease and acute coronary syndrome (ACS). In patients recovering after acute coronary syndrome these adipokines have not been studied until now.
    Material/Methods:    The subjects were 38 males, participants of 8 weeks early cardiac rehabilitation (ECR), started up to 30 days after percutaneous coronary intervention (PCI) for ACS. At admission and on final of the ECR every subject underwent anthropometric measurements, submaximal exercise test, and answered 24-hour dietary questionnaire. Venous blood samples were collected for adiponectin, leptin, and sObR serum concentrations and lipid profiles assessment.
    Results:    sObR serum concentration initially was 3917.11±1652.7 ng/dL and increased to 5097.63±1928.68 ng/dL after ECR (P<.01). Anthropometric parameters, dietary energy intake, lipid profiles, adiponectin, and leptin concentrations did not change significantly during the ECR. The energy expenditure on single training bout was significantly higher on the final training session comparing with the first one.
    Conclusions:    In male patients after ACS and primary PCI, attending ECR the sObR serum concentrations increased, presumably reflecting the decrease of leptin resistance. It should be considered a positive sign, possibly preceding other beneficial metabolic changes.

Keywords: soluble leptin receptor, ., adiponectin, leptin., cardiac rehabilitation,, acute coronary syndrome.

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