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Wiesław Tryniszewski, Mariusz Gadzicki, Magdalena Górska-Chrząstek, Zbigniew Maziarz, Jacek Rysz
Med Sci Tech 2010; 51(3-4): RA227-232
Background: Gout affects joints and other organs and often impairs the body asymptomatically. The aim of this study was to determine to what extent gout correlates with the changes in bone system and muscle perfusion. The influence of gout on bone mineralization, bone metabolism and muscle perfusion were assessed. The correlation between these and the diagnostic usefulness of the methods applied are discussed.
The study included 44 patients (ages 38–67) including 7 women (ages 59–67). Seventeen of the examined men were 35–45 years of age. Of the 44 total patients, 5 were normal weight (11%), 29 (66%) were overweight and 10 (23%) were obese. The disease duration was 5–10 years.
Material/Methods: The patients were examined for gout by specialists. Biochemical and hormonal blood tests were performed on parameters that influence bone mineralization and rotation, and muscle perfusion. BMD, T-score and Z-score of femoral bone neck were obtained, and muscle perfusion was assessed. With own methods and programs the bone metabolism and muscle perfusion indicators were assigned.
Results: In patients with gout, a decrease in BMD, together with the slowing of metabolic processes, was observed. When BMD increased, a decreased perfusion was observed. A strong positive correlation was observed between BMD and IBM (indicator of bone metabolism), and between BMI and the perfusion indicator. Improved perfusion caused the BMD and IBM to increase. IBM and BMD define the size of the disturbances and are important clinical parameters.
Conclusions: The bone metabolism disorder, osteopenia and osteoporosis may be caused by the destructive influence of gout on the bone system. In patients with gout, bone mineralization and IBM disturbances occur much earlier than in those without gout. The increase of IBM reflects the pace of the metabolic processes in the bone system. These methods complete the diagnostics of bone systems in patients with gout.
Keywords: gout, Metabolism, bone densitometry, scintigraphy