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The effect of intrauterine infection on newborn infants immune system

Małgorzata Banasik, Krzysztof Zeman, Jarosław Paśnik, Andrzej Malinowski, Przemysław Lewkowicz, Ewa Fornalczyk-Wachowska

Med Sci Tech 2006; 47(1): RA45-50

ID: 881492


Background. Diagnostics of a newborn infant’s immune system arouses widespread interest and a cord blood obtained during the delivery has a sufficient quantity to become a source of information on newborn immune system's condition. The objective of here in elaboration has been to evaluate the influence of end anger within trauterine infection on some parameters of newborn immune system. Materials and Methods. The research included 26 eutrophic newborns of both sexes, which foetal age has been determined to be over 38 weeks. 14 eutrophic newborns from physiological labours have been qualified to Group I. For Group II-has been qualified 12 newborn in fantsend angered with supposed in trauterinefetus infection. Results. It has been observed that the 12 newborns with supposed intrauterine infection show lower percentage of CD3/CD25 lymphocytes in cord blood and CD4 in venous blood, as well as weaker proliferating response to mitogenic stimulus. Neutrophils of newborns with infection show increased resting and after stimulating fMLP expression of CD11b receptor in cord blood and CD16a in venous blood, impaired spontaneous migration and chemotaxis, as well as increased ability to generate chemiluminescence after PMA stimulation. Conclusions. Intrauterine infection had no influence on infants neutrophils ability to phagocytosis. Intrauterine infection endanger's factor influence on the proliferating response of lymphocytes and disturb most of evaluated functions of neutrophils in cord and venous blood. (Clin. Exp. Med. Lett. 2006; 47(1):45-50)

Keywords: intrauterine infection, newborn, Neutrophils, Lymphocytes

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