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Dementia related to cerebrovascular diseases: concept, basic science and clinical implications

Tomasz Sobów

Med Sci Tech 2006; 47(3): RP139-146

ID: 881517

Cerebrovascular disease and dementia are extremely prevalent and disabling disorders affecting older people. Results of pathological investigations and epidemiological studies have raised the possibility that the two disorders may be causally related. The study of such causal as sociations may provide insights that may lead to the development of strategies intended to prevent or treat dementia more effectively. Cerebrovascular disease has many manifestations, some of which are strong causal factors in the development of future dementia. However, uncertainty and controversy exist regarding the presence and nature of the causal contribution of others. The development of potential therapeutic strategies for dementia is hindered by the lack of understanding of such relationships and the consequent difficulty inidentifying a clear phenotype of dementia occurring predominantly due to cerebrovascular disease. The field is ripe for further examination of the associations between vascular factors and dementia, and the mechanisms underlying such associations. The interface between basic and clinical science has much to of ferinclarifying the relations hips between ageing, vascular factors and cognitive decline in older people. (Clin. Exp. Med. Lett. 2006; 47(3):139-146)

Keywords: vascular dementia, Stroke, cerebrovascular disease, treatment

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