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Adiponectin-adipocytes-derived hormone and its multidirectional function

Aleksandra Brucka, Konrad Szosland, Krzysztof Szyłło, Andrzej Lewiński

Med Sci Tech 2007; 48(2): RP75-82

ID: 881545

Increasing morbidity and mortality from cardiovascular and neoplastic disorders is the effect of more frequent problem of obesity, isulinresistance and type 2 diabetes; not only in developed countries but in developing as well. Excess adipose tissue in particular compartments of human body is connected with numerous risk factors of artherosclerosis such as hyperinsulinaemia, hypertension, dylipidaemia, disregulations of glucose metabolism. Several studies that have been conducted so far, have focused on the patomechanism of mentioned disorders with a particular attention paid to metabolism of adipocytes. Plasma proteins derived from adipocytes have been observed, especially the one called adiponectin. Adiponectin is the protein product of apM1 gene expression. Identified receptors of adiponectin: Adipo- R1 and AdipoR2 are localised not only on adipocytes but also on hepatocytes and skeletal myocytes. Activation of the pleiotropic enzyme AMP-dependent protein kinase is integral to the signalling intracellular effects of adiponectin. The potential antiinflammatory and antiartherosclerotic effects of adiponectin activity, as well as inhibition of neoplastic tranformation originate from its influence on cellular adhesion molecules presentation and cytokines and growth factors production. Adiponectin, adipocytes-derived protein, appears in circulation in a form of hexamer or multimer. Considering the current data, adiponectin is an integral part of several signalling pathways of alive cell. There is obvious necessity of further researches on the precise role of adiponectin and prospective use of gained knowledge in clinical practice. (Clin Exp Med Lett 2007; 48(2): 75-82)

Keywords: Adiponectin, endometrial cancer, angogenesis, artherosclerosis, pcos

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