e-ISSN 2329-0072




Get your full text copy in PDF

Homocysteine levels are associated with the severity of coronary artery disease

Krzysztof Chiżyński, Janusz Kawiński

Med Sci Tech 2007; 48(2): RA127-130

ID: 881547

Introduction: The aim of the study was to analyze the occurrence of hyperhomocysteinemia in patients with coronary artery disease (CAD) and the effect of hyperhomocysteinemia on the severity of atherosclerotic lesions in coronary arteries. Material and Methods: The study group consisted of 250 males patients, aged 31 to 60 years, (mean age 48.9±6.6 yr.), with angiographically documented CAD, and 140 subjects (mean age 47.2±5.9 yr.) without CAD was the control group. Homocysteine concentration was assessed using fluorescence-polarization immunoassay test. Results: The mean level of homocysteine in patients with CAD was 16.83 μmol/l with the individual values ranging from 8.77 to 34.5 μmol/l. Hyperhomocysteinemia (homocysteine level >15.0 μmol/l) was diagnosed in 124 patients with CAD (49.6%). The level of homocysteine in the control group was 12.34 μmol/l (p<0.001). Hyperhomocysteinemia was diagnosed in 31 patients (22.1%) (p<0.001). An analysis was performed in the study group with the division into 1, 2 and 3-vessel stenoses to investigate the effect of homocysteine on the severity of atherosclerotic lesions. The mean level of homocysteine in patients with 1-vessel stenosis was 13.36 μmol/l and it was comparable to that in the patients without CAD. The level of homocysteine in induced atherosclerosis tended to be higher than in patients with 1 vessel stenosis, respectively 17.17 μmol/l and 17.48 μmol/l (p<0.001). Conclusions: 1. Hiperhomocysteinemia is a risk factor for coronary artery disease in Polish population. 2. Hiperhomocysteinemia is associated with the severity of coronary artery disease. (Clin Exp Med Lett 2007; 48(2): 127-130)

Keywords: Risk Factors, Hyperhomocysteinemia, Coronary Artery Disease

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree