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The risk of fatal cardiovascular diseases is greater in mild aortic stenosis than in advanced

Wojciech Gola, Małgorzata Lelonek

Med Sci Tech 2008; 49(1): RA15-18

ID: 881584

Introduction: Degenerative aortic stenosis (AS) as an inflammatory process is connected with atherosclerotic risk factors and diseases. This study was designed to evaluate risk factors and cardiovascular risk in AS related to mean aortic valve gradient (AVG). Material and Methods: This retrospective study contained 111 patients (mean age 65±8.94 yrs, 70% male) with degenerative AS. Patients were analyzed related to value of AVG: mild AS-group–AVG<50 mmHg (n = 61) and advanced AS-group–AVG≥50 mmHg (n = 50). The following data were analyzed: age, gender, BMI, serum lipids level, cholesterol ratio (total cholesterol/HDL), markers of inflammatory process (WBC, CRP), presence of hypertension, diabetes, CAD, smoking cigarettes and positive family history of cardiovascular diseases (CVD). We also determined total risk of fatal CVD used the SCORE system and 10 years of CAD risk based on Framingham studies. Results: Mild AS-group differed from advanced in gender distribution with male predominance (P<0.01), presence of CAD and hypertension (61% vs. 39% and 64% vs. 41%; P<0.05, respectively). The distribution of other analyzed clinical and laboratory parameters were similar in the studied groups. Mild AS-patients developed higher 10 years risk of fatal CVD than advanced AS-patients (95%CI 3%-5% vs. 4%-8%, P<0.03). For the studied groups the risk of CAD was 10%. Conclusions: The 10 year risk of fatal CVD was higher in mild than advanced AS-group. In patients without previous history of CAD the risk of its incidence was moderate unrelated to magnitude of AVG. We found no correlation between lipids level and markers of inflammatory process and AVG. (Clin Exp Med Lett 2008; 49(1): 15-18)

Keywords: aortic stenosis, cardiovascular risk, risk of CAD, aortic valve gradient

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