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Acute fatty liver of pregnancy

Katarzyna Gruber, Kinga Belowska-Bień, Rafał Poręba, Joanna Gruber, Maciej Podgórski, Andrzej Szuba, Ryszard Andrzejak

Med Sci Tech 2008; 49(1): RP5-13

ID: 881585

Acute fatty liver of pregnancy (AFLP) represents a rare but serious disease of the third trimester in pregnancy, with a high frequency of serious complications. Several authors suggest that some AFLP cases reflect inborn disturbance in foetal metabolism: the inborn deficiency of long-chain 3-hydroxyacyl-coenzyme A dehydrogenase. The disease manifests by non-specific prodromal symptoms, which are followed by jaundice, a pronounced liver failure with encephalopathy or coma and frequently with hypoglycaemia. Recognition of AFLP involves a clinical diagnosis: it is based on clinical signs/ symptoms and on abnormal laboratory indices. The differential diagnosis includes diseases specific for the second and the third trimester of pregnancy and diseases which may develop in any period of pregnancy. No specific treatment of the disease is available. The early diagnosis, prompt delivery and an appropriate adjunct therapy are of high significance for successful outcome for the mother and her foetus. (Clin Exp Med Lett 2008; 49(1): 5-13)

Keywords: liver disease in pregnancy, long-chain 3-hydroxyacyl-coenzyme A dehydrogenase (LCHAD) deficiency, acute fatty liver of pregnancy (AFLP), HELLP Syndrome, disseminated intravascular coagulation (DIC)

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