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Usefulness of measurement of c-terminal telopeptide of type i collagen in edentulous patients with resorption of mandibular bonebasis

Ewa Zmysłowska, Agnieszka Zmysłowska, Wojciech Młynarski, Kazimierz Jędrzejewski

Med Sci Tech 2008; 49(1): RA37-40

ID: 881593


[sup][/sup]Introduction: The aim of the study was an evaluation of concentration of osteocalcin and C-terminal telopeptide of type I collagen in edentulous patients with resorption of mandibular bonebasis and correlation between individual factors (age, sex, duration of edentulism) and degree of bone atrophy in mandible of edentulous patients. Material and methods: 35 edentulous patients aged between 51 and 89 years were studied. Serum levels of osteocalcin and C-terminal telopeptide of type I collagen were analyzed by RIA methods. Results: We observed mandibular atrophy in all studied subjects. No correlations between the age and gender of subjects, concentration of osteocalcin and value of IC/IM index were observed. A negative correlation was noted between the concentration of C-terminal telopeptide of type I collagen and value of IC/IM index (r= - 0.51, p=0.002 for the right side and r= - 0.47, p=0.005 left side of mandible). A correlation between duration of edentulism and the IC/IM index value for the right side of mandible (r = - 0.33, p< 0.05) and the left side (r= - 0.3, p=0.05) was observed. Conclusions: Our study indicated high usefulness of measurement of concentration of C-terminal telopeptide of type I collagen in monitoring of resorption of mandibular bonebasis in the edentulous patients. A concentration of osteocalcin is not related to the intensity of mandibular atrophy in the edentulous patients. Short duration of edentulism is associated with lower degree of mandibular atrophy. (Clin Exp Med Lett 2008; 49(1): 37-40)

Keywords: bonebasis resorption, Mandible, edentulism, C-terminal telopeptide of type 1 collagen, osteocalcin

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