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Dose and time-dependent influence of simvastatin on the ghrelin and leptin serum levels in normotensive and normocholesterolaemic rats

Jacek Owczarek, Magdalena Jasińska, Daria Orszulak–Michalak

Med Sci Tech 2008; 49(2): RA115-118

ID: 881598

Introduction: Statins have well-established role in prevention in cardiovascular diseases. Data indicate that obesity is the significant risk factor of cardiovascular morbidity. Ghrelin and leptin are the adipokines playing essential role in the regulation of energy homeostasis. Recent data suggested that ghrelin and leptin influenced on the cardiovascular activity. Aim: The estimation of the dose and time–dependent influence of simvastatin on ghrelin and leptin serum levels. Material and methods: Simvastatin in doses of 1, 10 and 20mg/kg bw or placebo were given intragastrically over two and four week period. Ghrelin and leptin were assayed in plasma by RIA kit. Results: Two and four week administration of simvastatin in dose of 1, 10 and 20 mg/kg/ bw resulted in similar changes in ghrelin concentration to group receiving placebo and between groups. Leptin serum concentration in group receiving placebo during 4 wk was 0,2856+/- 0,0042 ng/ml and during 2 wk was 0.2836 +/- 0.0033 ng/ml. Four weeks administration of simvastatin in all doses caused insignificant changes in leptin serum level as compared to group receiving placebo and between groups receiving simvastatin. Simvastatin administration in dose of 1 mg kg bw during 2 wk increased leptin serum level as compared to group receiving placebo (0,4343 +/- 0,0968 vs 0.2836 +/- 0.0033 ng/ml) and as compared to group receiving simvastatin in dose of 20 mg/kg bw (0,4343 +/- 0,0968 vs 0,2909 +/- 0,0615 ng/ml, p < 0.05). Conclusion: The influence of simvastatin after 2 wk administration on serum leptin level was showed. (Clin Exp Med Lett 2008; 49(2): 115-118)

Keywords: simvastatin, Ghrelin, Leptin, serum level

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