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Mass Spectrometry in Clinical Diagnostics

Joanna Piechowicz, Agnieszka Gajewska-Naryniecka, Maciej Kukula, Jerzy Wiśniewski, Andrzej Gamian

Med Sci Tech 2017; 58:98-110

DOI: 10.12659/MST.904021

ABSTRACT: The use of mass spectrometry (MS) in clinical diagnostics has increased in recent years. Development of liquid chromatography mass spectrometry (LC-MS) expanded the research capabilities of MS and also widens the scope of MS usage in this research area.
Currently, there are only a few routinely used MS-based diagnostic methods in comparison with the traditional clinical analysis systems, which are based on biochemical assays and immunoassays. There are well-documented cases of the superiority of liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays vs. immunoassays, especially for steroid analysis.
Clinical applications of MS can be divided into screening and target analysis. Screening procedures serves to detect multiple biomarkers of diseases, medicaments, or toxins. Accuracy, precision, and confirmation of the analyte identity are the main goals of target and quantitative analysis. This paper presents a review of application of MS-based techniques in clinical diagnostics.

Keywords: Gas Chromatography-Mass Spectrometry, Mass Spectrometry, Metabolomics, Proteomics

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